Publications at Yale

Y. Gao, J. T. Zimmer, R. Vasic, C. Liu, R. Gbyli, S. J. Zheng, A. Patel, W. Liu, Z. Qi, R. Nelakanti, Y. Song, G. Biancon, A. Z. Xiao, S. Slavoff, R. G. Kibbey, R. A. Flavell, M. D. Simon, T. Tebaldi, H. B. Li, S. Halene. “ALKBH5 modulates energy metabolism through m6A modification-mediated RNA stability control.” Cell Reports2023, 42(10):113163. Open access.

Y. Chen*, H. Su*, J. Zhao, Z. Na, K. Jiang, A. Bacchiocchi, K. H. Loh, R. Halaban, Z. Wang, X. Cao, S. A. Slavoff. “Unannotated microprotein EMBOW regulates the interactome and the chromatin and mitotic functions of WDR5.” Cell Reports, 2023, 42(9):113145. Open access.

J. J. Mohsen, A. Martel, S. A. Slavoff. “Microproteins - Discovery, Structure and Function.” Proteomics2023, early online

J. J. Mohsen, S. A. Slavoff. “Noncoding translation: quality control in the BAG.” Molecular Cell2023, 83(12):1967-1969.

Y. Chen*, X. Cao*, K. H. Loh, S. A. Slavoff. “Chemical labeling and identification of functional microproteins and alternative proteins.” Biochemical Society Transctions2023, 51(3):1071-1082. Open access.

X. Dai, J. J. Park, Y. Du, Z. Na, S. Z. Lam, R. D. Chow, P. A. Renauer, J. Gu, S. Xin, Z. Chu, C. Liao, P. Clark, H. Zhao, S. Slavoff, S. Chen. “Massively parallel knock-in engineering of human T cells.” Nature Biotechnology202341(9):1239-1255

X. Cao*, Y. Chen*, A. Khitun, S. A. Slavoff. “BONCAT-based profiling of nascent small and alternative open reading frame-encoded proteins.” Bio-protocol2023, 13(0):e4585. DOI: 10.21769/BioProtoc.4585. Open access

Z. Na*, X. Dai*, S. J. Zheng, C. J. Bryant, K. H. Loh, H. Su, Y. Luo, A. F. Buhagiar, X. Cao, S. J. Baserga, S. Chen, S. A. Slavoff. “Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID.” Molecular Cell2022, 82(15), 2900-2911.e7. PMC

X. Cao, A. Khitun, C. M. Harold, C. J. Bryant, S. J. Zheng, S. J. Baserga, S. A. Slavoff. “Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor.” Nature Chemical Biology2022, 18(6), 643-651. PMC

Z. Na*, Y. Luo*, D. Cui, A. Khitun, S. Smelyansky, J. P. Loria, S. A. Slavoff. “Phosphorylation of a human microprotein promotes dissociation of biomolecular condensates.” Journal of the American Chemical Society, 2021, 143(32), 12675-12687. PMC

X. Cao*, A. Khitun*, Y. Luo, Z. Na, T. Phoodokmai, K. Sappakhaw, E. Olatunji, C. Uttamapinant, S. A. Slavoff. “Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24.” Nature Communications, 2021, 12(508). Open access

K. Sappakhaw, K. Jantarug, S. A. Slavoff, N. Israsena, C. Uttamapinant. “A genetic code expansion-derived molecular beacon for the detection of intracellular amyloid-beta peptide generation.” Angewandte Chemie International Edition2021, 60, 3934-3939. PMC

Y. Luo, J. Schofield, Z. Na, T. Hann, M. D. Simon, S. A. Slavoff. “Discovery of cellular substrates of human RNA decapping enzyme Dcp2 using a stapled bicyclic peptide inhibitor.” Cell Chemical Biology, 2021, 28(4):463-474.e7. PMC

Y. Luo*, J. Schofield*, M. D. Simon, S. A. Slavoff. “Global profiling of cellular substrates of human Dcp2.” Biochemistry2020, 59(43), 4176-4188. PMC

Z. Na*, Y. Luo*, J. A. Schofield, S. Smelyansky, A. Khitun, S. Muthukumar, E. Valkov, M. D. Simon, S. A. Slavoff. “The NBDY microprotein regulates cellular RNA decapping.” Biochemistry2020, 59(42), 4131-4142. PMC

X. Cao*, A. Khitun*, Z. Na, D. Dumitrescu, M. Kubica, E. Olatunji, S. A. Slavoff. “Comparative proteomic profiling of unannotated microproteins and alternative proteins in human cell lines.” Journal of Proteome Research2020, 19(8), 3418-3426. PMC

X. Cao, S. A. Slavoff. “Non-AUG start codons: Expanding and regulating the small and alternative ORFeome.” Experimental Cell Research, 2020, 391(1), 111973. PMC

R. M. Brecht, C. C. Liu, H. A. Beilinson, A. Khitun, S. A. Slavoff, D. G. Schatz. “Nucleolar localization of RAG1 modulates V(D)J recombination activity.” Proceedings of the National Academy of Sciences, 2020, 117(8):4300-4309. PMC

A. Khitun, S. A. Slavoff. “Proteomic detection and validation of translated small open reading frames.” Current Protocols in Chemical Biology, 2019, 11(4):e77. PMC

A. Khitun*, T. Ness*, S. A. Slavoff. “Small open reading frames and cellular stress responses.” Molecular Omics, 2019, 15(2):108-116. PMC

R. Jackson, L. Kroehling, A. Khitun, W. Bailis, A. Jarret, A. G. York, O. M. Khan, J. R. Brewer, M. H. Skadow, C. Duizer, C. C. D. Harman, L. Chang, P. Bielecki, A. G. Solis, H. R. Steach, S. Slavoff, R. A. Flavell. “The translation of non-canonical open reading frames controls mucosal immunity.” Nature2018, 564(7736):434-438. PMC

Y. Luo*, Z. Na*, S. A. Slavoff. “P-bodies: composition, properties and functions.” Biochemistry, 201857(17): 2424-2431. PMC

R. Aebersold et al. “How many human proteoforms are there?” Nature Chemical Biology201814(3):206-214. PMC

P. Yuan, N. G. D’Lima, S. A. Slavoff. “Comparative membrane proteomics reveals a nonannotated E. coli heat shock protein.” Biochemistry, 2018, 57, 56-69. PMC

N. G. D’Lima*, A. Khitun*, A. D. Rosenbloom, P. Yuan, B. M. Gassaway, K. W. Barber, J. Rinehart, S. A. Slavoff. “Comparative proteomics enables identification of nonannotated cold shock proteins in E. coli.” Journal of Proteome Research, 2017, 13, 3722-3731. PMC

N. G. D’Lima, J. Ma, L. Winkler, Q. Chu, K. H. Loh, E. O. Corpuz, B. A. Budnik, J. Lykke-Andersen, A. Saghatelian, S. A. Slavoff. “A human microprotein that interacts with the mRNA decapping complex.” Nature Chemical Biology, 2017, 13, 174–180. PMC