Chemical tools to study RNA and microproteins

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study translation of small open reading frames, the functions of their encoded microproteins, and the spatiotemporal¬†regulation of RNA degradation in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function.¬†To learn more…


January 7, 2020
Dr. Shujian Zheng joins us as a postdoctoral fellow. Shujian received his Ph.D. in metabolomics and analytical chemistry at Wuhan University, and he will apply his mass spec...
November 19, 2019
We have received generous pilot funding to support our collaborative project with Dr. Ruth Halaban’s group in Yale Dermatology to develop innovative new melanoma...
October 18, 2019
Check out this great Science News article on the rapidly expanding universe of small open reading frames, featuring some of our work!