Welcome

Dark matter of the human genome

Welcome! We are a young lab in the Yale Institute of Biomolecular Design and Discovery. We are developing chemical and biological tools to study the “dark matter of the human genome” - previously undiscovered small open reading frames that encode microproteins - and their functions. We utilize a broad range of interdisciplinary methods, including proteomics, fluorescence microscopy, and peptide and small molecule synthesis, to probe the roles of microproteins in human cells and disease. To learn more…

News

January 5, 2023
Check out Xiongwen, Yanran and Alex’s new protocol, out today at Bio-protocol. They provide a detailed workflow for metabolic labeling, enrichment and proteomic...
September 1, 2022
Ayodya Jayatisa joins us as a postgraduate after completing her Master’s at Skoltech in biotechnology. She will identify microproteins associated with autoimmune...
August 29, 2022
Jessica Mohsen received a Roberts Fellowship from the Chemistry Department to support her studies on the function and regulatory mechanism of a bacterial microprotein...