Chemical tools to study RNA and microproteins

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study translation of small open reading frames, the functions of their encoded microproteins, and the spatiotemporal regulation of RNA degradation in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function. To learn more…


October 16, 2020
Congrats to Zhenkun, Vicky, and Stephanie - their paper describing the cellular function of the NBDY microprotein is online now at Biochemistry. They show that NBDY deletion...
August 17, 2020
Jessie Mohsen has been named to the Chemical Biology Training grant! Congratulations!
July 21, 2020
New graduate student Jessie Mohsen joins the lab! Jessie worked in the Seeman lab at NYU as an undergrad, and the Miranda lab at the Gladstone Institute as a postbac. She...