Dark matter of the human genome

Welcome! We are a young lab in the Yale Institute of Biomolecular Design and Discovery. We are developing chemical and biological tools to study the “dark matter of the human genome” - previously undiscovered small open reading frames that encode microproteins - and their functions. We utilize a broad range of interdisciplinary methods, including proteomics, fluorescence microscopy, and peptide and small molecule synthesis, to probe the roles of microproteins in human cells and disease. To learn more…


August 29, 2022
Jessica Mohsen received a Roberts Fellowship from the Chemistry Department to support her studies on the function and regulatory mechanism of a bacterial microprotein...
August 15, 2022
Kevin has been appointed to the Chemical Biology Training Grant, which will provide support for his studies on microproteins in melanoma. Congratulations, Kevin!
July 28, 2022
Check out Zhenkun Na and Xiaoyun Dai’s new work, online now at Molecular Cell. They developed a proximity biotinylation pipeline suitable for microprotein detection,...