Welcome

Dark matter of the human genome

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study the “dark matter of the human genome” - previously undiscovered small open reading frames that encode microproteins - and their functions, including spatiotemporal regulation of RNA function in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function. To learn more…

News

December 22, 2020
Vicky’s paper reporting a stapled peptide inhibitor of the human RNA decapping enzyme Dcp2 is out today at Cell Chemical Biology. Check out the article and West Campus...
October 16, 2020
Congrats to Zhenkun, Vicky, and Stephanie - their paper describing the cellular function of the NBDY microprotein is online now at Biochemistry. They show that NBDY deletion...