Dark matter of the human genome

Welcome! We are a young lab in the Yale Institute of Biomolecular Design and Discovery. We are developing chemical and biological tools to study the “dark matter of the human genome” - previously undiscovered small open reading frames that encode microproteins - and their functions, including spatiotemporal regulation of RNA in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function. To learn more…


September 5, 2021
Undergraduate researcher Dante Petruzziello has joined the group to study the regulation and function of a microbial microprotein. Welcome, Dante!
August 4, 2021
Zhenkun and Vicky’s paper describing regulation of liquid-liquid phase separation by the NoBody microprotein is out online today! This work shows for the first time...
July 12, 2021
Sarah has been honored with the 2020-21 Arthur Greer Memorial Prize for Outstanding Scholarly Publication or Research, awarded by the Yale Faculty of Arts and Sciences to...