Welcome

Chemical tools to study RNA and microproteins

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study translation of small open reading frames, the functions of their encoded microproteins, and the spatiotemporal regulation of RNA degradation in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function. To learn more…

News

May 25, 2020
Check out Xiongwen and Alex’s paper on quantitative profiling of unannotated proteins in leukemia cells, online now at the Journal of Proteome Research, featuring...
May 11, 2020
Vicky won first place for best oral presentation at the 2020 ACS New Haven Student Research Symposium. Great work! You can check out all of the student talks here.
May 4, 2020
Check out our collaboration with the Simon lab, online now at Biochemistry, to map and characterize the thousands of human transcripts regulated by the RNA decapping enzyme...