Dark matter of the human genome

Welcome! We are a young lab in the Yale Institute of Biomolecular Design and Discovery. We are developing chemical and biological tools to study the “dark matter of the human genome” - previously undiscovered small open reading frames that encode microproteins - and their functions. We utilize a broad range of interdisciplinary methods, including proteomics, fluorescence microscopy, and peptide and small molecule synthesis, to probe the roles of microproteins in human cells and disease. To learn more…