Dark matter of the human genome

Welcome! We are a young lab in the Yale Institute of Biomolecular Design and Discovery. We are developing chemical and biological tools to study the “dark matter of the human genome” - previously undiscovered small open reading frames that encode microproteins - and their functions, including spatiotemporal regulation of RNA in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function. To learn more…