Welcome

Dark matter of the human genome

Welcome! We are a young lab in the Yale Institute of Biomolecular Design and Discovery. We are developing chemical and biological tools to study the “dark matter of the human genome” - previously undiscovered small open reading frames that encode microproteins - and their functions. We utilize a broad range of interdisciplinary methods, including proteomics, fluorescence microscopy, and peptide and small molecule synthesis, to probe the roles of microproteins in human cells and disease. To learn more…

News

November 1, 2023
Thanks to ACS Chemical Biology and the ACS Division of Biological Chemistry for recognizing us with a 2024 ACS Chemical Biology Young Investigator Award! Every member of the...
September 19, 2023
Out today at Cell Reports, Yanran, Xiongwen, Haomiao and Kevin describe EMBOW, an unannotated microprotein that binds to WDR5 with far-reaching cellular consequences. The...
August 30, 2023
Nadiya Jaunbocus was selected to receive a Charlotte Fitch Roberts Research Fellowship Award by the Chemistry Department to support her projects to discover and engineer...