Chemical tools to study RNA translation, degradation, and trafficking

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study RNA and ribonucleoprotein particles. Specifically, we are interested in the identities and roles of non-canonical translation initiation sites, the spatiotemporal¬†regulation of RNA degradation in human cells, and cellular RNA trafficking. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and light- and small molecule-mediated control of biomolecular function.¬†To learn more…


June 26, 2017
We receive a 5-year grant from the National Institute of General Medical Sciences to support our work characterizing the structure and function of the NoBody microprotein....
June 14, 2017
The Leukemia Research Foundation has provided us a pilot grant to apply our quantitative, function-first proteomic pipeline to discovery of microproteins specifically...
May 26, 2017
Vicky Luo passed her qualifying exam today with flying colors and became our lab’s most recent Ph.D. candidate. No surprise - congrats!