Welcome

Chemical tools to study RNA translation, degradation, and trafficking

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study RNA and ribonucleoprotein particles. Specifically, we are interested in the identities and roles of non-canonical translation initiation sites, the spatiotemporal regulation of RNA degradation in human cells, and cellular RNA trafficking. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and light- and small molecule-mediated control of biomolecular function. To learn more…

News

December 5, 2016
Check out our new paper in Nature Chemical Biology, describing our discovery of NoBody, a microprotein translated from a “long non-coding RNA”. NoBody localizes to P-bodies (...
October 4, 2016
Dr. Zhenkun Na joins us after receiving his Ph.D. at NUS and a research assistantship at A*Star. He will be bringing his expertise on small-molecule inhibitors and structural...
August 29, 2016
Vicky receives a T.F. Cooke Award for excellence in teaching from the chemistry department, recognizing her great work as a teaching assistant. Congrats, Vicky, and thanks...