Chemical tools to study RNA translation, degradation, and trafficking

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study RNA and ribonucleoprotein particles. Specifically, we are interested in the identities and roles of non-canonical translation initiation sites, the spatiotemporal regulation of RNA degradation in human cells, and cellular RNA trafficking. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and light- and small molecule-mediated control of biomolecular function. To learn more…


September 1, 2017
Nadia and Alex’s paper, “Comparative proteomics enables identification of non-annotated cold shock proteins in E. coli”, is accepted at the Journal of Proteome Research...
August 25, 2017
Jessica gave a wonderful talk on her thesis project toward development of quantitative functional proteogenomics (and Sarah spoke, too) at the Chemistry Department Symposium...
August 17, 2017
We had a fun morning of paddle-boarding and eating pizza with our lab members and loved ones! Thanks everyone!