Welcome

Chemical tools to study RNA and microproteins

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study translation of small open reading frames, the functions of their encoded microproteins, and the spatiotemporal¬†regulation of RNA degradation in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function.¬†To learn more…

News

February 19, 2018
Dr. Travis Ness is joining us as a postdoctoral associate after completing his Ph.D. in chemical biology at Wayne State University, where he used creative enzymology to...
January 30, 2018
Vicky and Zhenkun update us on the current current knowledge of the composition and function of P-bodies. Check out the full text!
October 17, 2017
Jessica’s paper is out today! She developed a comparative proteomics method targeting membrane proteins and applied it to identification of a never-before-seen small¬†E...