Welcome

Chemical tools to study RNA and microproteins

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study translation of small open reading frames, the functions of their encoded microproteins, and the spatiotemporal regulation of RNA degradation in human cells. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and small molecule-mediated control of biomolecular function. To learn more…

News

October 17, 2017
Jessica’s paper is out today! She developed a comparative proteomics method targeting membrane proteins and applied it to identification of a never-before-seen small E...
September 1, 2017
Nadia and Alex’s paper, “Comparative proteomics enables identification of non-annotated cold shock proteins in E. coli”, is accepted at the Journal of Proteome Research...
August 25, 2017
Jessica gave a wonderful talk on her thesis project toward development of quantitative functional proteogenomics (and Sarah spoke, too) at the Chemistry Department Symposium...