Chemical tools to study RNA translation, degradation, and trafficking

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study RNA and ribonucleoprotein particles. Specifically, we are interested in the identities and roles of non-canonical translation initiation sites, the spatiotemporal regulation of RNA degradation in human cells, and cellular RNA trafficking. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and light- and small molecule-mediated control of biomolecular function. To learn more…


June 24, 2016
David Caianiello passed his qualifier today with flying colors! Great job - we knew you would crush it!
May 12, 2016
Alex passes her qualifying exam and becomes our very first Ph.D. candidate. Congratulations, we’re all proud of you!
April 14, 2016
We receive an award from the Searle Scholars Program to support our goals of studying translation initiation using genetic and proteomic techniques. We extend our deepest...