Chemical tools to study RNA translation, degradation, and trafficking

Welcome! We are a young lab in the Yale Chemical Biology Institute. We are developing chemical and biological tools to study RNA and ribonucleoprotein particles. Specifically, we are interested in the identities and roles of non-canonical translation initiation sites, the spatiotemporal regulation of RNA degradation in human cells, and cellular RNA trafficking. We utilize a broad range of interdisciplinary methods, including mass spectrometry-based proteomics, cellular imaging, chemical synthesis, and light- and small molecule-mediated control of biomolecular function. To learn more…


December 5, 2016
Check out our new paper in Nature Chemical Biology, describing our discovery of NoBody, a microprotein translated from a “long non-coding RNA”. NoBody localizes to P-bodies (...
November 21, 2016
Dahyana Arias passed her MB&B qualifying exam on Friday - great work! We knew you would do it!
October 4, 2016
Dr. Zhenkun Na joins us after receiving his Ph.D. at NUS and a research assistantship at A*Star. He will be bringing his expertise on small-molecule inhibitors and structural...