December 5, 2016
Check out our new paper in Nature Chemical Biology, describing our discovery of NoBody, a microprotein translated from a “long non-coding RNA”. NoBody localizes to P-bodies (co-localization of green, NoBody, and red, P-body, puncta in the image) - cytoplasmic mRNA decay-associated mRNA-protein granules - and can make them disappear entirely from cells when its expression increases. The human proteome is far more complex than we currently appreciate, and this proteomic ”dark matter” - like NoBody - can exhibit some remarkable functions!
You can also read about it in Yale News!